Chase is based on two detectives, Shounosuke Nanase and Koto Amekura, that are tipped off by an anonymous caller that an explosion five years prior, previously ruled an accident, was purposely set off to mask a murder, leading to a new investigation of the case.

Chase was developed by Arc System Works, by former staff members from the studio Cing, including director Taisuke Kanasaki. It is narratively and thematically similar to Hotel Dusk: Room 215 and Last Window: The Secret of Cape West, detective titles developed by Cing before its closure.